Consistent mutational paths predict eukaryotic thermostability
نویسندگان
چکیده
منابع مشابه
An expert system to predict protein thermostability using decision tree
Protein thermostability information is closely linked to commercial production of many biomaterials. Recent developments have shown that amino acid composition, special sequence patterns and hydrogen bonds, disulfide bonds, salt bridges and so on are of considerable importance to thermostability. In this study, we present a system to integrate these various factors that predict protein thermost...
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Some biological or chemical reactions need to be performed at high temperatures to decrease reaction time. However, many proteins are not very stable when heated. Research is needed that helps proteins to remain active and stable at high temperatures overcoming many limitations to their industrial applications. Recently we have shown that some structural features of proteins are related to the ...
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OBJECTIVES Fluoroquinolone resistance has been poorly studied in Legionella pneumophila, an intracellular pathogen responsible for legionellosis. Our goal was to further characterize molecular mechanisms involved in fluoroquinolone resistance in this species. METHODS Eight independent lineages were founded from a common fluoroquinolone-susceptible L. pneumophila ancestor and propagated by ser...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2013
ISSN: 1471-2148
DOI: 10.1186/1471-2148-13-7